Breast Cancer Biomarkers
Increasing levels
- Agalactosyl biantennary glycans G0F and glycans containing sLex epitope A3F1G1 and A2F1G1.
- Highly sialylated antenna fucosylated glycans1.
- Fucosylated and sialylated glycans
- High-mannose type structures.
- Fucosylated glycans.
Breast Cancer Biomarkers
Decreasing levels
- Decreased leveles of sialylated glycans.
References:
[1] R. Saldova, et al., Levels of specific serum N-glycans identify breast cancer patients with higher circulating tumor cell counts, Ann. Oncol. 22 (2011) 1113–1119.
[2] U.M. Abd Hamid, et al., A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression, Glycobiology 18 (2008) 1105
[3] Z. Kyselova, et al., Breast cancer diagnosis and prognosis through quantitative measurements of serum glycan profiles, Clin. Chem. 54 (2008) 1166–1175.
[4] A. Pierce, et al., Levels of specific glycans significantly distinguish lymph node–
[5] de Leoz, M. L., et al., (2011) High-mannose glycans are elevated during breast cancer progression. Mol. Cell. Proteomics 10, M110.00271
[6] Alley, W. R., Jr., et al., (2010) Chip-based reversed-phase liquid chromatography-mass spectrometry of permethylated N-linked glycans: a potential methodology for cancerbiomarker discovery. Anal. Chem. 82, 5095–5106