Colon Cancer Biomarkers
Increse levels
- Levels of FUT3-7 and FUT9, responsible for a1,3-4 fucosylation at haptoglobin Asn241.
References:
[26] Kukowska-Latallo JF, et al., A cloned human cDNA determines expression of a mouse stagespecific embryonic antigen and the Lewis blood group a(1,3/1,4)fucosyltransferase. Genes Dev 1990;4:1288–303.
[27] Hanski C, et al., Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue. Glycoconj J 1996;13:727–33.
[28] Majuri ML, et al., Expression and function of a2,3-sialyl- and a,3/l,4- fucosyltransferases in colon adenocarcinoma cell lines: role in synthesis of E-selectin counter-receptors. Int J Cancer 1995;63:551–9.