IgA Nephropathy Biomarkers
Increasing levels
- IgG and IgM variable region glycans containing one or more oligomannose sugars. Significant increase in potential glycosylation sites in the variable region.Agalactosyl biantennary glycans G0F and glycans containing sLex epitope A3F1G1 and A2F1G1.
IgA Nephropathy Biomarkers
Decreasing levels
- Aberrant O-glycosylation of serum IgA1 in patients is ascribed to a decrease in terminal galactosylation and sialylation.
References:
[32] Arnold, J. N:, et al., The impact of glycosylation on the biological function and structure of human immunoglobulins. Annu. Rev. Immunol. 25, 21-50 (2007).