Rheumatoid arthritis, Systemic lupus erythrematosus, Sjogren’s syndrome, Juvenile-onset chronic arthritis, Crohn´s syndrome, Tuberculosis Biomarkers
Increasing levels
- Elevated proportion of IgG G0 glycoforms.
Rheumatoid arthritis, Systemic lupus erythrematosus, Sjogren’s syndrome, Juvenile-onset chronic arthritis, Crohn´s syndrome, Tuberculosis Biomarkers
Increasing levels
- Reduced degree of antennae sialylation and galactosylation for IgG N glycans.
References:
[29] Ercan et al. Hypogalactosylation of serum N-glycans fails to predict clinical response to m and TNF inhibition in rheumatoid arthritis.Arthritis Research & Therapy 2012, 14:R43.
[30] James N. Arnold et al., Mannan binding lectin and its interaction with immunoglobulins inhealth and in disease, Immunology Letters 106 (2006) 103–110.
[31] Pauline M. Rudd et al. Glycosylation and the Immune System. Science 291, 2370 (2001).
[32] Arnold, J. N:, et al., The impact of glycosylation on the biological function and structure of human immunoglobulins. Annu. Rev. Immunol. 25, 21-50 (2007).